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However, evidence of their effectiveness consists mainly of studies with poor methodologic design.In addition, these drugs have not been proven to be superior to acetaminophen or nonsteroidal anti-inflammatory drugs for low back pain.Cyclobenzaprine is the most heavily studied and has been shown to be effective for various musculoskeletal conditions.The sedative properties of tizanidine and cyclobenzaprine may benefit patients with insomnia caused by severe muscle spasms.This makes no sense to me, knowing what I do about APs in general. I was on Seroquel XR years ago at like 800mg a day and it did not phase me as far as daytime sedation. It gave me deadly heart arrythmias and pre diabetes. I am currently on seroquel right now at 100mg a day. I have a very very difficult time sleeping without it as I suffered insomnia many times before. Rozerem helped for a while, but is like a tic tac now. i was on 300mg to stop a manic episode, i took it at 6 pm and was asleep by 9.....
At very low doses (25-100 mg), quetiapine acts primarily as a histamine receptor blocker (antihistamine) and alpha-adrenergic blocker.
I`ve been told that at 50-100mg seroquel can be more sedating then at the higher doses.
Apparently seroquel uses different receptors at 50-100mg then at the higher doses. Quetiapine is a second-generation or "atypical" antipsychotic that works by counteracting serotonin, dopamine, histamine, and alpha-adrenergic receptors in the brain.
Methocarbamol and metaxalone are less sedating, although effectiveness evidence is limited.
Adverse effects, particularly dizziness and drowsiness, are consistently reported with all skeletal muscle relaxants.